Holding K + concentration constant prevented generation of the infra-slow fluctuations. In the network model simulating resting awake-like brain state, we observed infra-slow fluctuations in the extracellular K + concentration, Na +/K + pump activation, firing rate of neurons, and local field potentials. The computational model implemented dynamics for intra- and extracellular K + and Na + and intracellular Cl − ions, Na +/K + exchange pump, and KCC2 cotransporter. Here, using a detailed computational model of the brain network, we show that spontaneous infra-slow (<0.05 Hz) activity could originate due to the ion concentration dynamics. However, the origin of these infra-slow resting-state fluctuations remains unknown. These fluctuations were found to be correlated across brain regions and are thought to reflect neuronal activity fluctuations between functionally connected areas of the brain. ![]() ![]() Resting- or baseline-state low-frequency (0.01–0.2 Hz) brain activity is observed in fMRI, EEG, and local field potential recordings.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |